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Livres
Articles (92)
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Transgenic models of Alzheimer’s disease: Learning from animals

Tara L. Spires, Bradley T. Hyman

Journal:

Neurotherapeutics

Année:

2005

Langue:

english

Fichier:

PDF, 290 KB

english, 2005

Potassium channels in squid neuron cell bodies: Comparison to axonal channels

Tara Nealey, Sherrill Spires, Ruth Anne Eatock, Ted Begenisich

Journal:

Journal of Membrane Biology

Année:

1993

Langue:

english

Fichier:

PDF, 987 KB

english, 1993

Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo

Fulga, Tudor A., Elson-Schwab, Ilan, Khurana, Vikram, Steinhilb, Michelle L., Spires, Tara L., Hyman, Bradley T., Feany, Mel B.

Journal:

Nature Cell Biology

Année:

2006

Langue:

english

Fichier:

PDF, 2.80 MB

english, 2006

Tau pathophysiology in neurodegeneration: a tangled issue

Tara L. Spires-Jones, William H. Stoothoff, Alix de Calignon, Phillip B. Jones, Bradley T. Hyman

Journal:

Trends in Neurosciences

Année:

2009

Langue:

english

Fichier:

PDF, 906 KB

english, 2009

The intersection of amyloid beta and tau in glutamatergic synaptic dysfunction and collapse in Alzheimer's disease

Crimins, Johanna L., Pooler, Amy, Polydoro, Manuela, Luebke, Jennifer I., Spires-Jones, Tara L.

Journal:

Ageing Research Reviews

Année:

2013

Langue:

english

Fichier:

PDF, 703 KB

english, 2013

The clinical promise of biomarkers of synapse damage or loss in Alzheimerâs disease

Colom-Cadena, MartÃ, Spires-Jones, Tara, Zetterberg, Henrik, Blennow, Kaj, Caggiano, Anthony, DeKosky, Steven T., Fillit, Howard, Harrison, John E., Schneider, Lon S., Scheltens, Phillip, de Haan, Wi

Journal:

Alzheimer's Research & Therapy

Année:

2020

Fichier:

PDF, 2.04 MB

2020

T cell mediated cerebral hemorrhages and microhemorrhages during passive Aβ immunization in APPPS1 transgenic mice

Melanie Meyer-Luehmann, J Rodrigo Mora, Matthew Mielke, Tara L Spires-Jones, Alix de Calignon, Ulrich H von Andrian, Bradley T Hyman

Journal:

Molecular Neurodegeneration

Année:

2011

Langue:

english

Fichier:

PDF, 5.00 MB

english, 2011

Alzheimer's disease: synapses gone cold

Robert M Koffie, Bradley T Hyman, Tara L Spires-Jones

Journal:

Molecular Neurodegeneration

Année:

2011

Langue:

english

Fichier:

PDF, 361 KB

english, 2011

Are Tangles as Toxic as They Look?

Tara L. Spires-Jones, Katherine J. Kopeikina, Robert M. Koffie, Alix de Calignon, Bradley T. Hyman

Journal:

Journal of Molecular Neuroscience

Année:

2011

Langue:

english

Fichier:

PDF, 282 KB

english, 2011

Erratum to: Are Tangles as Toxic as They Look?

Tara L. Spires-Jones, Katherine J. Kopeikina, Robert M. Koffie, Alix de Calignon, Bradley T. Hyman

Journal:

Journal of Molecular Neuroscience

Année:

2011

Langue:

english

Fichier:

PDF, 40 KB

english, 2011

Dendritic spine pathology and deficits in experience-dependent dendritic plasticity in R6/1 Huntington's disease transgenic mice

Tara L. Spires, Helen E. Grote, Sylvia Garry, Patricia M. Cordery, Anton Van Dellen, Colin Blakemore, Anthony J. Hannan

Journal:

European Journal of Neuroscience

Année:

2004

Langue:

english

Fichier:

PDF, 409 KB

english, 2004

Molecular mechanisms mediating pathological plasticity in Huntington's disease and Alzheimer's disease

Tara L. Spires, Anthony J. Hannan

Journal:

Journal of Neurochemistry

Année:

2007

Langue:

english

Fichier:

PDF, 584 KB

english, 2007

Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport

Will Stoothoff, Phillip B. Jones, Tara L. Spires-Jones, Daniel Joyner, Ekta Chhabra, Kathryn Bercury, Zhanyun Fan, Hong Xie, Brian Bacskai, Jon Edd, Daniel Irimia, Bradley T. Hyman

Journal:

Journal of Neurochemistry

Année:

2009

Langue:

english

Fichier:

PDF, 580 KB

english, 2009

Nature, nurture and neurology: gene–environment interactions in neurodegenerative disease : FEBS Anniversary Prize Lecture delivered on 27 June 2004 at the 29th FEBS Congress in Warsaw

Tara L. Spires, Anthony J. Hannan

Journal:

FEBS Journal

Année:

2005

Langue:

english

Fichier:

PDF, 315 KB

english, 2005

Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease

Meyer-Luehmann, Melanie, Spires-Jones, Tara L., Prada, Claudia, Garcia-Alloza, Monica, de Calignon, Alix, Rozkalne, Anete, Koenigsknecht-Talboo, Jessica, Holtzman, David M., Bacskai, Brian J., Hyman,

Journal:

Nature

Année:

2008

Langue:

english

Fichier:

PDF, 1.02 MB

english, 2008

Caspase activation precedes and leads to tangles

de Calignon, Alix, Fox, Leora M., Pitstick, Rose, Carlson, George A., Bacskai, Brian J., Spires-Jones, Tara L., Hyman, Bradley T.

Journal:

Nature

Année:

2010

Langue:

english

Fichier:

PDF, 457 KB

english, 2010

A single dose of passive immunotherapy has extended benefits on synapses and neurites in an Alzheimer's disease mouse model

Anete Rozkalne, Tara L. Spires-Jones, Edward A. Stern, Bradley T. Hyman

Journal:

Brain Research

Année:

2009

Langue:

english

Fichier:

PDF, 860 KB

english, 2009

Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease

Tara L. Spires-Jones, Matthew L. Mielke, Anete Rozkalne, Melanie Meyer-Luehmann, Alix de Calignon, Brian J. Bacskai, Dale Schenk, Bradley T. Hyman

Journal:

Neurobiology of Disease

Année:

2009

Langue:

english

Fichier:

PDF, 745 KB

english, 2009

Calcineurin inhibition with FK506 ameliorates dendritic spine density deficits in plaque-bearing Alzheimer model mice

Anete Rozkalne, Bradley T. Hyman, Tara L. Spires-Jones

Journal:

Neurobiology of Disease

Année:

2011

Langue:

english

Fichier:

PDF, 1.04 MB

english, 2011

Wheel running from a juvenile age delays onset of specific motor deficits but does not alter protein aggregate density in a mouse model of Huntington's disease

Anton van Dellen, Patricia M Cordery, Tara L Spires, Colin Blakemore, Anthony J Hannan

Journal:

BMC Neuroscience

Année:

2008

Langue:

english

Fichier:

PDF, 384 KB

english, 2008

Tau Accumulation Causes Mitochondrial Distribution Deficits in Neurons in a Mouse Model of Tauopathy and in Human Alzheimer's Disease Brain

Katherine J. Kopeikina, George A. Carlson, Rose Pitstick, Adam E. Ludvigson, Alan Peters, Jennifer I. Luebke, Robert M. Koffie, Matthew P. Frosch, Bradley T. Hyman, Tara L. Spires-Jones

Journal:

The American Journal of Pathology

Année:

2011

Langue:

english

Fichier:

PDF, 3.73 MB

english, 2011

Calcineurin inhibition with systemic FK506 treatment increases dendritic branching and dendritic spine density in healthy adult mouse brain

Tara L. Spires-Jones, Kevin Kay, Roland Matsouka, Anete Rozkalne, Rebecca A. Betensky, Bradley T. Hyman

Journal:

Neuroscience Letters

Année:

2011

Langue:

english

Fichier:

PDF, 330 KB

english, 2011

Spine tingling polymorphisms—Is apolipoprotein E involved in dendritic shape and plasticity?

Tara L. Spires, Bradley T. Hyman

Journal:

Neurobiology of Aging

Année:

2007

Langue:

english

Fichier:

PDF, 58 KB

english, 2007

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

Alix de Calignon, Manuela Polydoro, Marc Suárez-Calvet, Christopher William, David H. Adamowicz, Kathy J. Kopeikina, Rose Pitstick, Naruhiko Sahara, Karen H. Ashe, George A. Carlson, Tara L. Spires-Jo

Journal:

Neuron

Année:

2012

Langue:

english

Fichier:

PDF, 4.88 MB

english, 2012

Monitoring protein aggregation and toxicity in Alzheimer’s disease mouse models using in vivo imaging

Tara L. Spires-Jones, Alix de Calignon, Melanie Meyer-Luehmann, Brian J. Bacskai, Bradley T. Hyman

Journal:

Methods

Année:

2011

Langue:

english

Fichier:

PDF, 913 KB

english, 2011

Region-specific Dissociation of Neuronal Loss and Neurofibrillary Pathology in a Mouse Model of Tauopathy

Tara L. Spires, Jennifer D. Orne, Karen SantaCruz, Rose Pitstick, George A. Carlson, Karen H. Ashe, Bradley T. Hyman

Journal:

The American Journal of Pathology

Année:

2006

Langue:

english

Fichier:

PDF, 2.21 MB

english, 2006

Impaired Spine Stability Underlies Plaque-Related Spine Loss in an Alzheimer's Disease Mouse Model

Tara L. Spires-Jones, Melanie Meyer-Luehmann, Jennifer D. Osetek, Phillip B. Jones, Edward A. Stern, Brian J. Bacskai, Bradley T. Hyman

Journal:

The American Journal of Pathology

Année:

2007

Langue:

english

Fichier:

PDF, 904 KB

english, 2007

S2-02-05: Neuritic alterations and dysfunctions in Alzheimer’s disease

Bradley T. Hyman, Tara Spires, Toshifumi Matsui, Jen Orne, Rose Pitstik, George A. Carlson, Karen Ashe

Journal:

Alzheimer's & Dementia

Année:

2006

Langue:

english

Fichier:

PDF, 55 KB

english, 2006

P1-090: Observation of new senile plaque formation and associated neuritic abnormalities using multiphoton microscopy

Melanie Meyer-Luehmann, Tara L. Spires, Brian J. Bacskai, Bradley T. Hyman

Journal:

Alzheimer's & Dementia

Année:

2006

Langue:

english

Fichier:

PDF, 62 KB

english, 2006

A transgenic model of the earliest stage of Alzheimer's disease

Bradley T. Hyman, Alix de Calignon, Marc Suarez-Calvet, Christopher William, Rose Pitstick, George A. Carlson, Tara L. Spires-Jones

Journal:

Alzheimer's & Dementia

Année:

2010

Langue:

english

Fichier:

PDF, 38 KB

english, 2010

APOE4 plays a role in Abeta-mediated synapse loss in Alzheimer's disease

David Holtzman, Bradley Hyman, Virginia Lee, Tara Spires-Jones, Robert Koffie, Tadafumi Hashimoto, Daniel Joyner, Steven Hou, Katherine Kopeikina, Matthew Frosch

Journal:

Alzheimer's & Dementia

Année:

2011

Langue:

english

Fichier:

PDF, 77 KB

english, 2011

Soluble forms of tau are toxic in Alzheimer’s disease

Kopeikina, Katherine J., Hyman, Bradley T., Spires-Jones, Tara L.

Journal:

Translational Neuroscience

Année:

2012

Langue:

english

Fichier:

PDF, 988 KB

english, 2012

Orchestrated experience-driven Arc responses are disrupted in a mouse model of Alzheimer's disease

Rudinskiy, Nikita, Hawkes, Jonathan M, Betensky, Rebecca A, Eguchi, Megumi, Yamaguchi, Shun, Spires-Jones, Tara L, Hyman, Bradley T

Journal:

Nature Neuroscience

Année:

2012

Langue:

english

Fichier:

PDF, 1.16 MB

english, 2012

Synaptic alterations in the rTg4510 mouse model of tauopathy

Kopeikina, Katherine J., Polydoro, Manuela, Tai, Hwan-Ching, Yaeger, Erich, Carlson, George A., Pitstick, Rose, Hyman, Bradley T., Spires-Jones, Tara L.

Journal:

The Journal of Comparative Neurology

Année:

2013

Langue:

english

Fichier:

PDF, 3.53 MB

english, 2013

The Synaptic Accumulation of Hyperphosphorylated Tau Oligomers in Alzheimer Disease Is Associated With Dysfunction of the Ubiquitin-Proteasome System

Tai, Hwan-Ching, Serrano-Pozo, Alberto, Hashimoto, Tadafumi, Frosch, Matthew P., Spires-Jones, Tara L., Hyman, Bradley T.

Journal:

The American Journal of Pathology

Année:

2012

Langue:

english

Fichier:

PDF, 2.12 MB

english, 2012

Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer’s disease model

Polydoro, Manuela, Dzhala, Volodymyr I., Pooler, Amy M., Nicholls, Samantha B., McKinney, A. Patrick, Sanchez, Laura, Pitstick, Rose, Carlson, George A., Staley, Kevin J., Spires-Jones, Tara L., Hyman

Journal:

Acta Neuropathologica

Année:

2014

Langue:

english

Fichier:

PDF, 1.65 MB

english, 2014

Tau-amyloid interactions in the rTgTauEC model of early Alzheimer's disease suggest amyloid-induced disruption of axonal projections and exacerbated axonal pathology

Pooler, Amy M., Polydoro, Manuela, Wegmann, Susanne K., Pitstick, Rose, Kay, Kevin R., Sanchez, Laura, Carlson, George A., Gomez-Isla, Teresa, Albers, Mark W., Spires-Jones, Tara L., Hyman, Bradley T.

Journal:

The Journal of Comparative Neurology

Année:

2013

Langue:

english

Fichier:

PDF, 1.08 MB

english, 2013

Methylene blue does not reverse existing neurofibrillary tangle pathology in the rTg4510 mouse model of tauopathy

Spires-Jones, Tara L., Friedman, Taylor, Pitstick, Rose, Polydoro, Manuela, Roe, Allyson, Carlson, George A., Hyman, Bradley T.

Journal:

Neuroscience Letters

Année:

2014

Langue:

english

Fichier:

PDF, 2.24 MB

english, 2014

P3-434

Spires, Tara L., Meyer-Luehmann, Melanie, Orne, Jennifer D., Backskai, Brian J., Hyman, Bradley T.

Journal:

Alzheimer's & Dementia

Année:

2006

Langue:

english

Fichier:

PDF, 69 KB

english, 2006

P1-486: Decreased neuronal activity in APP transgenic mice measured via dendritic protein synthesis

Meyer-Luehmann, Melanie, Stoothoff, Will, Spires-Jones, Tara L., Kowa, Tomo, Koker, Mirjam, Han, Kelly, Hyman, Bradley T.

Journal:

Alzheimer's & Dementia

Année:

2008

Langue:

english

Fichier:

PDF, 54 KB

english, 2008

P2-164: In vivo multiphoton imaging of neurofibrillary tangles: Relationship to cell death cascades

de Calignon, Alix, Spires-Jones, Tara, Hyman, Bradley T.

Journal:

Alzheimer's & Dementia

Année:

2008

Langue:

english

Fichier:

PDF, 59 KB

english, 2008

Caspase cleavage of tau is critical for oligomeric beta-amyloid–induced sub-lethal apoptotic cascade

Polydoro, Manuela, Hudry, Eloise, Perez-Nievas, Beatriz, Arbel-Ornath, Michal, Sanchez, Laura, Spires-Jones, Tara, Reumers, Veerle, Gómez-Isla, Teresa, Hyman, Bradley

Journal:

Alzheimer's & Dementia

Année:

2013

Langue:

english

Fichier:

PDF, 67 KB

english, 2013

Neurofibrillary tangles remain functionally integrated in cortical networks

Kuchibhotla, Kishore, Wegmann, Susanne, Spires-Jones, Tara, Bacskai, Brian, Hyman, Bradley

Journal:

Alzheimer's & Dementia

Année:

2013

Langue:

english

Fichier:

PDF, 43 KB

english, 2013

Changes in the progression of amyloid deposition in APP/PS mice after overexpression of different ApoE isoforms through intraventricular injection of an adeno-associated virus serotype 4

Hudry, Eloise, Hashimoto, Tadafumi, Scheel, Maria, Dashkoff, Jon, Spires-Jones, Tara, Bacskai, Brian, Davidson, Beverly, Hyman, Bradley

Journal:

Alzheimer's & Dementia

Année:

2011

Langue:

english

Fichier:

PDF, 75 KB

english, 2011

Differential central pathology and cognitive impairment in pre-diabetic and diabetic mice

Ramos-Rodriguez, Juan Jose, Ortiz, Oscar, Jimenez-Palomares, Margarita, Kay, Kevin R., Berrocoso, Esther, Murillo-Carretero, Maria Isabel, Perdomo, German, Spires-Jones, Tara, Cozar-Castellano, Irene,

Journal:

Psychoneuroendocrinology

Année:

2013

Langue:

english

Fichier:

PDF, 1.48 MB

english, 2013

The Synthesis of Megatubes: New Dimensions in Carbon Materials

Mitchell, Daniel R., Brown, R. Malcolm, Spires, Tara L., Romanovicz, Dwight K., Lagow, Richard J.

Journal:

Inorganic Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 666 KB

english, 2001

[IEEE 2007 IEEE/NIH Life Science Systems and Applications Workshop - Bethesda, MD, USA (2007.11.8-2007.11.9)] 2007 IEEE/NIH Life Science Systems and Applications Workshop - An automatic method for spine detection and spine tracking in in vivo images

Jing Fan,, Xiaobo Zhou,, Dy, Jennifer G., Yong Zhang,, Spires, Tara L., Hyman, Bradley T., Wong, Stephen T.C.

Année:

2007

Langue:

english

Fichier:

PDF, 196 KB

english, 2007

Clearing the way for tau immunotherapy in Alzheimer's disease

Herrmann, Abigail, Spires-Jones, Tara

Journal:

Journal of Neurochemistry

Année:

2015

Langue:

english

Fichier:

PDF, 422 KB

english, 2015

Pathological Tau Disrupts Ongoing Network Activity

Menkes-Caspi, Noa, Yamin, Hagar G., Kellner, Vered, Spires-Jones, Tara L., Cohen, Dana, Stern, Edward A.

Journal:

Neuron

Année:

2015

Langue:

english

Fichier:

PDF, 1.48 MB

english, 2015

Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer’s disease

Tai, Hwan-Ching, Wang, Bo Y, Serrano–Pozo, Alberto, Frosch, Matthew P, Spires-Jones, Tara L, Hyman, Bradley T

Journal:

Acta Neuropathologica Communications

Année:

2014

Langue:

english

Fichier:

PDF, 3.40 MB

english, 2014